Their upcoming quarter-final clash may have a familiar feel but Paul Gustard says that it’s high time Harlequins once again made their presence felt in Europe.

Quins go to Premiership Rugby rivals Worcester Warriors in the last eight of the Challenge Cup on Saturday (kick-off 8.15pm), having failed to reach the quarter-finals in their last two continental campaigns – in the Champions Cup and Challenge Cup respectively.

This weekend’s showdown at Sixways represents a welcome return to knockout rugby for the three-time Challenge Cup winners, who were also beaten finalists in the 2015-16 season, and Gustard is keen to see his troops make the most of it.

“We are pleased to have reached the knockout stages of European rugby for the first time in three years but now we want – and we need – to forge and create a new history at the club,” said Quins’ director of rugby.

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“Worcester against Harlequins is always a strong, competitive fixture, and we have had two good contests against them this year.

“I have no doubt that Saturday will be another one and it is one that we look forward to.”

Two Quins players are also set to reach personal milestones against Worcester, with prop Will Collier making his 150th appearance for the club and wing Ross Chisholm his 100th.

Gustard said: “Both Ross and Will have served the club with distinction over the past decade, both on and off the field.

“They are great professionals and both have made a huge contribution this season as we have progressed in the Premiership and in Europe.

“We are proud to acknowledge their individual achievements this weekend.”

Chisholm, 28, will be part of a back line that sees two changes from Quins’ 27-20 loss to London rivals Saracens last time out, with Alofa Alofa in at outside centre and Cadan Murley returning to the right wing in place of Joe Marchant and Nathan Earle respectively.

Meanwhile, Collier represents one of four changes up front, with Lewis Boyce replacing the injured Joe Marler, George Merrick coming in to the second row, Jack Clifford moving to number eight and Renaldo Bothma being named at blindside flanker.

Kyle Sinckler and Alex Dombrandt are rested, with Matt Symons also missing out.